The nutritional reality of GLP-1 therapy

A 2026 narrative review published in Clinical Obesity covering six studies and 480,825 adults, found that GLP-1 medications create measurable nutrient deficiencies through three mechanisms:

  • Appetite suppression: You eat 30-50% less, reducing vitamin and mineral intake proportionally

  • Delayed gastric emptying: Your body absorbs nutrients differently

  • GI side effects: Nausea and vomiting further reduce nutrient retention

These are the underlying drivers of the fatigue, hair thinning, muscle cramps, and mood changes that GLP-1 users report.

Clinical evidence

What the research shows

480,825

adults studied across six clinical trials in a peer-reviewed narrative review

Urbina et al. · Clinical Obesity · 2026

13.6%

Developed Vitamin D deficiency within 12 months of starting GLP-1 therapy

26%+

Higher iron depletion rates in GLP-1 users compared to matched controls

54%

Of patients on GLP-1 therapy developed B12 deficiency in follow-up studies

39%

Of weight lost on GLP-1s can be lean muscle mass without nutritional intervention

Sources: Urbina et al., Clinical Obesity (2026) · Butsch et al., Obesity Pillars (2025) · Melis et al., Diabetes, Obesity and Metabolism (2025)

Ingredient evidence

Why each ingredient is here

Vitamin B12

1,125% DV

GLP-1 therapy reduces B12 absorption. Deficiency causes the persistent fatigue most users report. High dose ensures adequate levels even with compromised absorption.

Biotin

1,000% DV

Rapid weight loss triggers telogen effluvium — temporary hair shedding that begins 2-4 months into therapy. Biotin supports keratin production and follicle health.

Chromium picolinate

343% DV

Supports blood sugar regulation during metabolic transition. We use picolinate — the most bioavailable form and most studied in clinical trials.

Zinc

136% DV

Listed as a key nutrient of concern for GLP-1 users. Supports immune function, skin integrity, and protein synthesis during body composition change.

Folate

167% DV

Reduced food volume means less folate from leafy greens. Critical for DNA repair, cellular turnover, and mood regulation.

Vitamin D3

50% DV

13.6% of GLP-1 users develop D deficiency within 12 months. Our formula provides neccesary support.

Magnesium

12% DV

Supports muscle function and sleep.

The research is clear

The solution is Simple

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